Thalidomide-NH-amido-C2-NH2 hydrochloride

Cat. No.: HY-138849A: Fiche technique Instruction de manipulation
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Thalidomide-NH-amido-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

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Thalidomide-NH-amido-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2983057-90-3

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Other Forms of Thalidomide-NH-amido-C2-NH2 hydrochloride:

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Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates:

Voir toutes les isoformes

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Activité biologique
Pureté et documentation
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Description

Thalidomide-NH-amido-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

409.82

Formule

C₁₇H₂₀ClN₅O₅

CAS No.

2983057-90-3

SMILES

O=C(C(CC1)N2C(C3=CC=CC(NCC(NCCN)=O)=C3C2=O)=O)NC1=O.[H]Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]