2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. E3 Ligase Ligand-linker Conjugate 222

E3 Ligase Ligand-linker Conjugate 222 is a E3 ligase ligand-linker conjugate that incorporates a CRBN (Thalidomide) ligand and a linker. E3 Ligase Ligand-linker Conjugate 222 can be connected to the target protein ligand to form a SK5527 PROTAC (HY-179641).

For research use only. We do not sell to patients.

E3 Ligase Ligand-linker Conjugate 222

E3 Ligase Ligand-linker Conjugate 222 Chemical Structure

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E3 Ligase Ligand-linker Conjugate 222 Related Antibodies

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Description

E3 Ligase Ligand-linker Conjugate 222 is a E3 ligase ligand-linker conjugate that incorporates a CRBN (Thalidomide) ligand and a linker. E3 Ligase Ligand-linker Conjugate 222 can be connected to the target protein ligand to form a SK5527 PROTAC (HY-179641)[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E3 Ligase Ligand-linker Conjugate 222 Related Antibodies
Molecular Weight

490.57

Formula

C24H35FN6O4
SMILES

O=C(CC1)NC(N1C(C=N2)=CC=C2N(CC3)CCN3CC4(F)CCN(C(OC(C)(C)C)=O)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E3 Ligase Ligand-linker Conjugate 222 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 Ligase Ligand-linker Conjugate 222E3 Ligase Ligand-Linker ConjugatesE3 ligase ligand-linker conjugateCRBNPROTACInhibitorinhibitorinhibit

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Product Name:
E3 Ligase Ligand-linker Conjugate 222
Cat. No.:
HY-179644
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