(S,R,S)-AHPC-Me-CO-C6-COOH

Cat. No.: HY-W998311 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
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(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C6-COOH can be used to synthesize PROTAC.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me-CO-C6-COOH Chemical Structure

CAS No. : 2365173-02-8

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C6-COOH can be used to synthesize PROTAC.

IC₅₀ & Target

VHL

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

600.78

Formula

C₃₁H₄₄N₄O₆S

CAS No.

2365173-02-8

Appearance

Solid

Color

White to light yellow

SMILES

C([C@@H](NC(CCCCCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (166.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6645 mL	8.3225 mL	16.6450 mL
5 mM	0.3329 mL	1.6645 mL	3.3290 mL
10 mM	0.1665 mL	0.8323 mL	1.6645 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.0%

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Data Sheet (246 KB) SDS (394 KB)

COA (254 KB) HNMR (300 KB) LCMS (327 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6645 mL	8.3225 mL	16.6450 mL	41.6126 mL
	5 mM	0.3329 mL	1.6645 mL	3.3290 mL	8.3225 mL
	10 mM	0.1665 mL	0.8323 mL	1.6645 mL	4.1613 mL
	15 mM	0.1110 mL	0.5548 mL	1.1097 mL	2.7742 mL
	20 mM	0.0832 mL	0.4161 mL	0.8323 mL	2.0806 mL
	25 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6645 mL
	30 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3871 mL
	40 mM	0.0416 mL	0.2081 mL	0.4161 mL	1.0403 mL
	50 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8323 mL
	60 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6935 mL
	80 mM	0.0208 mL	0.1040 mL	0.2081 mL	0.5202 mL
	100 mM	0.0166 mL	0.0832 mL	0.1665 mL	0.4161 mL