(S,R,S)-AHPC-Me-CO-C6-COOH
Based on 1 Customer Validation
(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C6-COOH can be used to synthesize PROTAC.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2365173-02-8
- Formula: C31H44N4O6S
- Molecular Weight:600.78
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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VHL |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2365173-02-8
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Appearance Solid
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Molecular Weight 600.78
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Formula C31H44N4O6S
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Color White to light yellow
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SMILES
C([C@@H](NC(CCCCCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (166.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (246 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6645 mL | 8.3225 mL | 16.6450 mL | 41.6126 mL |
| 5 mM | 0.3329 mL | 1.6645 mL | 3.3290 mL | 8.3225 mL | |
| 10 mM | 0.1665 mL | 0.8323 mL | 1.6645 mL | 4.1613 mL | |
| 15 mM | 0.1110 mL | 0.5548 mL | 1.1097 mL | 2.7742 mL | |
| 20 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 2.0806 mL | |
| 25 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6645 mL | |
| 30 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3871 mL | |
| 40 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 1.0403 mL | |
| 50 mM | 0.0333 mL | 0.1665 mL | 0.3329 mL | 0.8323 mL | |
| 60 mM | 0.0277 mL | 0.1387 mL | 0.2774 mL | 0.6935 mL | |
| 80 mM | 0.0208 mL | 0.1040 mL | 0.2081 mL | 0.5202 mL | |
| 100 mM | 0.0166 mL | 0.0832 mL | 0.1665 mL | 0.4161 mL |
(S,R,S)-AHPC-Me-CO-C6-COOH Related Classifications
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