Thalidomide-4-O-C5-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 96.87%
- CAS No.: 2419145-66-5
- Formula: C18H22ClN3O5
- Molecular Weight:395.84
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2419145-66-5
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Appearance Solid
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Molecular Weight 395.84
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Formula C18H22ClN3O5
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Color White to off-white
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCN)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (252.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5263 mL | 12.6314 mL | 25.2627 mL | 63.1568 mL |
| 5 mM | 0.5053 mL | 2.5263 mL | 5.0525 mL | 12.6314 mL | |
| 10 mM | 0.2526 mL | 1.2631 mL | 2.5263 mL | 6.3157 mL | |
| 15 mM | 0.1684 mL | 0.8421 mL | 1.6842 mL | 4.2105 mL | |
| 20 mM | 0.1263 mL | 0.6316 mL | 1.2631 mL | 3.1578 mL | |
| 25 mM | 0.1011 mL | 0.5053 mL | 1.0105 mL | 2.5263 mL | |
| 30 mM | 0.0842 mL | 0.4210 mL | 0.8421 mL | 2.1052 mL | |
| 40 mM | 0.0632 mL | 0.3158 mL | 0.6316 mL | 1.5789 mL | |
| 50 mM | 0.0505 mL | 0.2526 mL | 0.5053 mL | 1.2631 mL | |
| 60 mM | 0.0421 mL | 0.2105 mL | 0.4210 mL | 1.0526 mL | |
| 80 mM | 0.0316 mL | 0.1579 mL | 0.3158 mL | 0.7895 mL | |
| 100 mM | 0.0253 mL | 0.1263 mL | 0.2526 mL | 0.6316 mL |
Thalidomide-4-O-C5-NH2 hydrochloride Related Classifications
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