Pomalidomide-piperazine hydrochloride
Based on 1 Customer Validation
Pomalidomide-piperazine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
For research use only. We do not sell to patients.
- Purity: ≥97.0%
- CAS No.: 2230956-83-7
- Formula: C17H19ClN4O4
- Molecular Weight:378.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2230956-83-7
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Appearance Solid
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Molecular Weight 378.81
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Formula C17H19ClN4O4
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Color Light yellow to yellow
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SMILES
O=C1NC(C(CC1)N2C(C3=CC=CC(N4CCNCC4)=C3C2=O)=O)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (263.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (249 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6398 mL | 13.1992 mL | 26.3985 mL | 65.9961 mL |
| 5 mM | 0.5280 mL | 2.6398 mL | 5.2797 mL | 13.1992 mL | |
| 10 mM | 0.2640 mL | 1.3199 mL | 2.6398 mL | 6.5996 mL | |
| 15 mM | 0.1760 mL | 0.8799 mL | 1.7599 mL | 4.3997 mL | |
| 20 mM | 0.1320 mL | 0.6600 mL | 1.3199 mL | 3.2998 mL | |
| 25 mM | 0.1056 mL | 0.5280 mL | 1.0559 mL | 2.6398 mL | |
| 30 mM | 0.0880 mL | 0.4400 mL | 0.8799 mL | 2.1999 mL | |
| 40 mM | 0.0660 mL | 0.3300 mL | 0.6600 mL | 1.6499 mL | |
| 50 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3199 mL | |
| 60 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.0999 mL | |
| 80 mM | 0.0330 mL | 0.1650 mL | 0.3300 mL | 0.8250 mL | |
| 100 mM | 0.0264 mL | 0.1320 mL | 0.2640 mL | 0.6600 mL |
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