Thalidomide-O-amide-C5-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 95.51%
- CAS No.: 2716130-28-6
- Formula: C20H25ClN4O6
- Molecular Weight:452.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
Chemical Information
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CAS No. 2716130-28-6
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Appearance Solid
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Molecular Weight 452.89
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Formula C20H25ClN4O6
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Color Off-white to light yellow
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SMILES
O=C(NCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (110.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2080 mL | 11.0402 mL | 22.0804 mL | 55.2010 mL |
| 5 mM | 0.4416 mL | 2.2080 mL | 4.4161 mL | 11.0402 mL | |
| 10 mM | 0.2208 mL | 1.1040 mL | 2.2080 mL | 5.5201 mL | |
| 15 mM | 0.1472 mL | 0.7360 mL | 1.4720 mL | 3.6801 mL | |
| 20 mM | 0.1104 mL | 0.5520 mL | 1.1040 mL | 2.7601 mL | |
| 25 mM | 0.0883 mL | 0.4416 mL | 0.8832 mL | 2.2080 mL | |
| 30 mM | 0.0736 mL | 0.3680 mL | 0.7360 mL | 1.8400 mL | |
| 40 mM | 0.0552 mL | 0.2760 mL | 0.5520 mL | 1.3800 mL | |
| 50 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL | |
| 60 mM | 0.0368 mL | 0.1840 mL | 0.3680 mL | 0.9200 mL | |
| 80 mM | 0.0276 mL | 0.1380 mL | 0.2760 mL | 0.6900 mL | |
| 100 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL |
Thalidomide-O-amide-C5-NH2 hydrochloride Related Classifications
HY-W998329 Related Classifications
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