2716130-28-6
Chemical Structure
Thalidomide-O-amide-C5-NH2 hydrochloride
- CAS No.: 2716130-28-6
- Formula:C20H25ClN4O6
- Molecular Weight:452.89
InChIKey: ZKCWBVKAAVYCJY-UHFFFAOYSA-N
SMILES: O=C(NCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl
Biological Activity: Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1][2].
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Thalidomide-O-amide-C5-NH2 hydrochloride | 95.51% | Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||||||||||||||||||
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- [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
- [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]