1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Glutarimide-Isoindolinone-NH-PEG3-COOH

Glutarimide-Isoindolinone-NH-PEG3-COOH 

Cat. No.: HY-138791 Purity: 99.12%
Handling Instructions

Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Glutarimide-Isoindolinone-NH-PEG3-COOH Chemical Structure

Glutarimide-Isoindolinone-NH-PEG3-COOH Chemical Structure

Size Price Stock Quantity
50 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

463.48

Formula

C22H29N3O8

SMILES

O=C1N(CC2=CC(NCCOCCOCCOCCC(O)=O)=CC=C21)C3C(NC(CC3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (64.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1576 mL 10.7880 mL 21.5759 mL
5 mM 0.4315 mL 2.1576 mL 4.3152 mL
10 mM 0.2158 mL 1.0788 mL 2.1576 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Glutarimide-Isoindolinone-NH-PEG3-COOH
Cat. No.:
HY-138791
Quantity:
MCE Japan Authorized Agent: