2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide 5-fluoride 6-piperidine-C-OH

Thalidomide 5-fluoride 6-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

For research use only. We do not sell to patients.

Thalidomide 5-fluoride 6-piperidine-C-OH

Thalidomide 5-fluoride 6-piperidine-C-OH Chemical Structure

CAS No. : 2505501-99-3

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Thalidomide 5-fluoride 6-piperidine-C-OH Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide 5-fluoride 6-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide 5-fluoride 6-piperidine-C-OH Related Antibodies
Molecular Weight

389.38

Formula

C19H20FN3O5
CAS No.
Appearance

Solid

SMILES

O=C1C2=CC(F)=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCC(CO)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (256.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5682 mL 12.8409 mL 25.6819 mL
5 mM 0.5136 mL 2.5682 mL 5.1364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5682 mL 12.8409 mL 25.6819 mL 64.2046 mL
5 mM 0.5136 mL 2.5682 mL 5.1364 mL 12.8409 mL
10 mM 0.2568 mL 1.2841 mL 2.5682 mL 6.4205 mL
15 mM 0.1712 mL 0.8561 mL 1.7121 mL 4.2803 mL
20 mM 0.1284 mL 0.6420 mL 1.2841 mL 3.2102 mL
25 mM 0.1027 mL 0.5136 mL 1.0273 mL 2.5682 mL
30 mM 0.0856 mL 0.4280 mL 0.8561 mL 2.1402 mL
40 mM 0.0642 mL 0.3210 mL 0.6420 mL 1.6051 mL
50 mM 0.0514 mL 0.2568 mL 0.5136 mL 1.2841 mL
60 mM 0.0428 mL 0.2140 mL 0.4280 mL 1.0701 mL
80 mM 0.0321 mL 0.1605 mL 0.3210 mL 0.8026 mL
100 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6420 mL
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Thalidomide 5-fluoride 6-piperidine-C-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide 5-fluoride 6-piperidine-C-OH2505501-99-3E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Thalidomide 5-fluoride 6-piperidine-C-OH
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