Thalidomide 5-fluoride 6-piperidine-C-OH
Based on 1 Customer Validation
Thalidomide 5-fluoride 6-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
For research use only. We do not sell to patients.
- Purity: 98.35%
- CAS No.: 2505501-99-3
- Formula: C19H20FN3O5
- Molecular Weight:389.38
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2505501-99-3
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Appearance Solid
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Molecular Weight 389.38
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Formula C19H20FN3O5
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Color Light yellow to yellow
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SMILES
O=C1C2=CC(F)=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCC(CO)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (256.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (242 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5682 mL | 12.8409 mL | 25.6819 mL | 64.2046 mL |
| 5 mM | 0.5136 mL | 2.5682 mL | 5.1364 mL | 12.8409 mL | |
| 10 mM | 0.2568 mL | 1.2841 mL | 2.5682 mL | 6.4205 mL | |
| 15 mM | 0.1712 mL | 0.8561 mL | 1.7121 mL | 4.2803 mL | |
| 20 mM | 0.1284 mL | 0.6420 mL | 1.2841 mL | 3.2102 mL | |
| 25 mM | 0.1027 mL | 0.5136 mL | 1.0273 mL | 2.5682 mL | |
| 30 mM | 0.0856 mL | 0.4280 mL | 0.8561 mL | 2.1402 mL | |
| 40 mM | 0.0642 mL | 0.3210 mL | 0.6420 mL | 1.6051 mL | |
| 50 mM | 0.0514 mL | 0.2568 mL | 0.5136 mL | 1.2841 mL | |
| 60 mM | 0.0428 mL | 0.2140 mL | 0.4280 mL | 1.0701 mL | |
| 80 mM | 0.0321 mL | 0.1605 mL | 0.3210 mL | 0.8026 mL | |
| 100 mM | 0.0257 mL | 0.1284 mL | 0.2568 mL | 0.6420 mL |
Thalidomide 5-fluoride 6-piperidine-C-OH Related Classifications
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