2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. A 410099.1, amine-Boc hydrochloride

A 410099.1, amine-Boc hydrochloride 

Cat. No.: HY-136269 Purity: 95.03%
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A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5).

For research use only. We do not sell to patients.

A 410099.1, amine-Boc hydrochloride Chemical Structure

A 410099.1, amine-Boc hydrochloride Chemical Structure

CAS No. : 2374122-37-7

Size Price Stock Quantity
25 mg USD 520 In-stock
50 mg USD 830 In-stock
100 mg USD 1250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of A 410099.1, amine-Boc hydrochloride:

A 410099.1, amine-Boc hydrochloride Related Antibodies

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Description

A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5)[1].

IC50 & Target

cIAP1

 

Molecular Weight

620.22

Formula

C32H50ClN5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C[C@H]1N)[C@@H](C1)C(N[C@H]2C3=CC=CC=C3CCC2)=O)[C@H](C4CCCCC4)NC([C@H](C)N(C)C(OC(C)(C)C)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6123 mL 8.0617 mL 16.1233 mL
5 mM 0.3225 mL 1.6123 mL 3.2247 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6123 mL 8.0617 mL 16.1233 mL 40.3083 mL
5 mM 0.3225 mL 1.6123 mL 3.2247 mL 8.0617 mL
10 mM 0.1612 mL 0.8062 mL 1.6123 mL 4.0308 mL
15 mM 0.1075 mL 0.5374 mL 1.0749 mL 2.6872 mL
20 mM 0.0806 mL 0.4031 mL 0.8062 mL 2.0154 mL
25 mM 0.0645 mL 0.3225 mL 0.6449 mL 1.6123 mL
30 mM 0.0537 mL 0.2687 mL 0.5374 mL 1.3436 mL
40 mM 0.0403 mL 0.2015 mL 0.4031 mL 1.0077 mL
50 mM 0.0322 mL 0.1612 mL 0.3225 mL 0.8062 mL
60 mM 0.0269 mL 0.1344 mL 0.2687 mL 0.6718 mL
80 mM 0.0202 mL 0.1008 mL 0.2015 mL 0.5039 mL
100 mM 0.0161 mL 0.0806 mL 0.1612 mL 0.4031 mL
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A 410099.1, amine-Boc hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A 410099.1, amine-Boc2374122-37-7E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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