2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-piperazine-tert-butyl formate

Thalidomide-piperazine-tert-butyl formate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

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Thalidomide-piperazine-tert-butyl formate

Thalidomide-piperazine-tert-butyl formate Chemical Structure

CAS No. : 2222120-27-4

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Thalidomide-piperazine-tert-butyl formate Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-piperazine-tert-butyl formate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-piperazine-tert-butyl formate Related Antibodies
Masse moléculaire

428.49

Formule

C22H28N4O5
CAS No.
SMILES

O=C(OC(C)(C)C)N1CCN(C2=CC=C3C(=O)N(CC3=C2)C4C(=O)NC(=O)CC4)CC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Thalidomide-piperazine-tert-butyl formate Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-piperazine-tert-butyl formate2222120-27-4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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