1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-C3-NH2 TFA

(S,R,S)-AHPC-C3-NH2 TFA (Synonyms: VH032-C3-NH2 TFA)

Cat. No.: HY-130711A
Handling Instructions

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C3-NH2 TFA Chemical Structure

(S,R,S)-AHPC-C3-NH2 TFA Chemical Structure

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Description

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

629.69

Formula

C₂₈H₃₈F₃N₅O₆S

SMILES

OC(C(F)(F)F)=O.NCCCC(N[[email protected]](C(N1[[email protected]@H](C[[email protected]](C1)O)C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

(S,R,S)-AHPC-C3-NH2VH032-C3-NH2E3 Ligase Ligand-Linker ConjugateEED-TargetedVH032VHLPROTAClinkerInhibitorinhibitorinhibit

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Product name:
(S,R,S)-AHPC-C3-NH2 TFA
Cat. No.:
HY-130711A
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