1. Epigenetics
    PROTAC
  2. Histone Methyltransferase
    PROTAC
  3. UNC6852

UNC6852 

Cat. No.: HY-130708
Handling Instructions

UNC6852 is a selective rolycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand, with an IC50 of 247 nM for EED.

For research use only. We do not sell to patients.

UNC6852 Chemical Structure

UNC6852 Chemical Structure

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Description

UNC6852 is a selective rolycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand, with an IC50 of 247 nM for EED[1].

IC50 & Target

IC50: 247 nM (EED)[1]

In Vitro

UNC6852 mediates PRC2 degradation[1].
UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells[1].
UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2[1].
UNC6852 facilitates PRC2 degradation via VHL recruitment[1].
UNC6852 selectively degrades EED and EZH2[1].
UNC6852 reduces H3K27me3 levels and DLBCL cell proliferation[1].

Cell Proliferation Assay[1]

Cell Line: DLBCL Cells
Concentration: 3 μM
Incubation Time: 0 -10 days
Result: Exhibited anti-proliferative effects.

Western Blot Analysis[1]

Cell Line: HeLa Cells
Concentration: 10 μM
Incubation Time: 1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours
Result: Resulted in a decrease in the levels of both EED and EZH2.
Molecular Weight

832.97

Formula

C₄₃H₄₈N₁₀O₆S

SMILES

O=C(C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4)NCCCC(N[[email protected]](C(N5[[email protected]@H](C[[email protected]](C5)O)C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)=O)C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

UNC6852UNC 6852UNC-6852Histone MethyltransferasePROTACProteolysis-targeting chimeraPRC2EEDInhibitorinhibitorinhibit

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UNC6852
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HY-130708
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