(S,R,S)-AHPC-C3-NH2 hydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 96.68%
- CAS No.: 2940858-65-9
- Formula: C26H38ClN5O4S
- Molecular Weight:552.13
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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VHL |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2940858-65-9
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Appearance Solid
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Molecular Weight 552.13
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Formula C26H38ClN5O4S
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Color Light yellow to yellow
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SMILES
NCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O.[H]Cl
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Synonyms
VH032-C3-NH2 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (181.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8112 mL | 9.0558 mL | 18.1117 mL | 45.2792 mL |
| 5 mM | 0.3622 mL | 1.8112 mL | 3.6223 mL | 9.0558 mL | |
| 10 mM | 0.1811 mL | 0.9056 mL | 1.8112 mL | 4.5279 mL | |
| 15 mM | 0.1207 mL | 0.6037 mL | 1.2074 mL | 3.0186 mL | |
| 20 mM | 0.0906 mL | 0.4528 mL | 0.9056 mL | 2.2640 mL | |
| 25 mM | 0.0724 mL | 0.3622 mL | 0.7245 mL | 1.8112 mL | |
| 30 mM | 0.0604 mL | 0.3019 mL | 0.6037 mL | 1.5093 mL | |
| 40 mM | 0.0453 mL | 0.2264 mL | 0.4528 mL | 1.1320 mL | |
| 50 mM | 0.0362 mL | 0.1811 mL | 0.3622 mL | 0.9056 mL | |
| 60 mM | 0.0302 mL | 0.1509 mL | 0.3019 mL | 0.7547 mL | |
| 80 mM | 0.0226 mL | 0.1132 mL | 0.2264 mL | 0.5660 mL | |
| 100 mM | 0.0181 mL | 0.0906 mL | 0.1811 mL | 0.4528 mL |
(S,R,S)-AHPC-C3-NH2 hydrochloride Related Classifications
HY-130711B Related Classifications
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