2688842-02-4
Chemical Structure
(S,R,S)-AHPC-C3-NH2 TFA
Synonym(s): VH032-C3-NH2 TFA
- CAS No.: 2688842-02-4
- Formula:C28H38F3N5O6S
- Molecular Weight:629.69
IUPAC Name: (2S,4R)-1-((S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
InChIKey: MDVHDVIBUKXMTL-XUXADIIKSA-N
SMILES: OC(C(F)(F)F)=O.NCCCC(N[C@H](C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C)=O
Biological Activity: (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1].
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(S,R,S)-AHPC-C3-NH2 TFA | (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader. | |||||||||||||||||||||
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Keywords
