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Cat. No.: HY-181748

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VHL Ligand-Linker Conjugates 18

VHL Ligand-Linker Conjugates 18 is an E3 ligase ligand-linker conjugate containing an E3 ligase ligand (HY-181791) and a linker. VHL Ligand-Linker Conjugates 18 can be used for the synthesis of PROTACs, such as DOT1L808 (HY-181789).

For research use only. We do not sell to patients.

Formula: C₃₈H₅₇FN₈O₅S
Molecular Weight:756.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VHL Ligand-Linker Conjugates 18 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

VHL

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 756.97
Formula C₃₈H₅₇FN₈O₅S
SMILES

CC1=C(SC=N1)C2=CC=C(C(OCCN3CCN(CC3)CCN4CCNCC4)=C2)CNC([C@@H]5C[C@H](CN5C([C@H](C(C)(C)C)NC(C6(CC6)F)=O)=O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Quan S, et al. Development of DOT1L-Targeted Protein Degraders for Treating MLL-r Leukemia. J Med Chem. 2026;69(4):4439-4468. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VHL Ligand-Linker Conjugates 18

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VHL Ligand-Linker Conjugates 18 Related Classifications

HY-181748 Related Classifications