Thalidomide-PEG5-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 95.18%
- CAS No.: 2703775-06-6
- Formula: C23H32ClN3O9
- Molecular Weight:529.97
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2703775-06-6
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Appearance Oil
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Molecular Weight 529.97
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Formula C23H32ClN3O9
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Color Light yellow to yellow
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SMILES
NCCOCCOCCOCCOCCOC1=CC(C(N2C(C3=O)CCC(N3)=O)=O)=C(C=C1)C2=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (235.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1005. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8869 mL | 9.4345 mL | 18.8690 mL | 47.1725 mL |
| 5 mM | 0.3774 mL | 1.8869 mL | 3.7738 mL | 9.4345 mL | |
| 10 mM | 0.1887 mL | 0.9434 mL | 1.8869 mL | 4.7172 mL | |
| 15 mM | 0.1258 mL | 0.6290 mL | 1.2579 mL | 3.1448 mL | |
| 20 mM | 0.0943 mL | 0.4717 mL | 0.9434 mL | 2.3586 mL | |
| 25 mM | 0.0755 mL | 0.3774 mL | 0.7548 mL | 1.8869 mL | |
| 30 mM | 0.0629 mL | 0.3145 mL | 0.6290 mL | 1.5724 mL | |
| 40 mM | 0.0472 mL | 0.2359 mL | 0.4717 mL | 1.1793 mL | |
| 50 mM | 0.0377 mL | 0.1887 mL | 0.3774 mL | 0.9434 mL | |
| 60 mM | 0.0314 mL | 0.1572 mL | 0.3145 mL | 0.7862 mL | |
| 80 mM | 0.0236 mL | 0.1179 mL | 0.2359 mL | 0.5897 mL | |
| 100 mM | 0.0189 mL | 0.0943 mL | 0.1887 mL | 0.4717 mL |
Thalidomide-PEG5-NH2 hydrochloride Related Classifications
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