2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-5-O-C4-NH2 hydrochloride

Thalidomide-5-O-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker.

For research use only. We do not sell to patients.

Thalidomide-5-O-C4-NH2 hydrochloride

Thalidomide-5-O-C4-NH2 hydrochloride Chemical Structure

CAS No. : 2694727-93-8

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Thalidomide-5-O-C4-NH2 hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-5-O-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker[1].

IC50 & Target

Cereblon

 

In Vitro

Thalidomide-5-O-C4-NH2 hydrochloride is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Thalidomide-5-O-C4-NH2 hydrochloride can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-5-O-C4-NH2 hydrochloride Related Antibodies
Molecular Weight

381.81

Formula

C17H20ClN3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C=CC(OCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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Thalidomide-5-O-C4-NH2 hydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-5-O-C4-NH22694727-93-8E3 Ligase Ligand-Linker ConjugatesMolecular gelcereblon ligandPROTACCRBN proteintarget protein ligandconjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-5-O-C4-NH2 hydrochloride
Cat. No.:
HY-149561
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