E3 Ligase Ligand-linker Conjugate 223
E3 Ligase Ligand-linker Conjugate 223 is a E3 ligase ligand-linker conjugate that incorporates a CRBN (Thalidomide) ligand and a linker. E3 Ligase Ligand-linker Conjugate 223 can be connected to the target protein ligand to form a PROTAC SK4454 (HY-179640) .
For research use only. We do not sell to patients.
- Formula: C24H36N6O4
- Molecular Weight:472.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 472.58
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Formula C24H36N6O4
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SMILES
O=C(CC1)NC(N1C(C=N2)=CC=C2N(CC3)CCN3CC4CCN(C(OC(C)(C)C)=O)CC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E3 Ligase Ligand-linker Conjugate 223 Related Classifications
HY-179642 Related Classifications
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