Thalidomide-NH-C5-NH2 TFA

Cat. No.: HY-43941 Purity: 97.02%: Data Sheet
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Thalidomide-NH-C5-NH2 (TFA) is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

For research use only. We do not sell to patients.

Thalidomide-NH-C5-NH2 TFA Chemical Structure

CAS No. : 2093386-40-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Other Forms of Thalidomide-NH-C5-NH2 TFA:

Thalidomide-NH-C5-NH2 Get quote

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•Related Screening Libraries:

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View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-NH-C5-NH2 (TFA) is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

472.42

Formula

C₂₀H₂₃F₃N₄O₆

CAS No.

2093386-40-2

Appearance

Solid

SMILES

O=C(O)C(F)(F)F.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCN)C3C2=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (211.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1168 mL	10.5838 mL	21.1676 mL
5 mM	0.4234 mL	2.1168 mL	4.2335 mL
10 mM	0.2117 mL	1.0584 mL	2.1168 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.02%

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Data Sheet (244 KB) SDS (393 KB)

COA (249 KB) HNMR (193 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1168 mL	10.5838 mL	21.1676 mL	52.9190 mL
	5 mM	0.4234 mL	2.1168 mL	4.2335 mL	10.5838 mL
	10 mM	0.2117 mL	1.0584 mL	2.1168 mL	5.2919 mL
	15 mM	0.1411 mL	0.7056 mL	1.4112 mL	3.5279 mL
	20 mM	0.1058 mL	0.5292 mL	1.0584 mL	2.6460 mL
	25 mM	0.0847 mL	0.4234 mL	0.8467 mL	2.1168 mL
	30 mM	0.0706 mL	0.3528 mL	0.7056 mL	1.7640 mL
	40 mM	0.0529 mL	0.2646 mL	0.5292 mL	1.3230 mL
	50 mM	0.0423 mL	0.2117 mL	0.4234 mL	1.0584 mL
	60 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8820 mL
	80 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6615 mL
	100 mM	0.0212 mL	0.1058 mL	0.2117 mL	0.5292 mL