Thalidomide-5-propargyne-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 2490402-62-3
- Formula: C16H14ClN3O4
- Molecular Weight:347.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2490402-62-3
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Appearance Solid
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Molecular Weight 347.75
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Formula C16H14ClN3O4
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Color Light yellow to light brown
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SMILES
O=C1C2=CC=C(C=C2C(N1C3C(NC(CC3)=O)=O)=O)C#CCN.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 83.33 mg/mL (239.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8756 mL | 14.3781 mL | 28.7563 mL | 71.8907 mL |
| 5 mM | 0.5751 mL | 2.8756 mL | 5.7513 mL | 14.3781 mL | |
| 10 mM | 0.2876 mL | 1.4378 mL | 2.8756 mL | 7.1891 mL | |
| 15 mM | 0.1917 mL | 0.9585 mL | 1.9171 mL | 4.7927 mL | |
| 20 mM | 0.1438 mL | 0.7189 mL | 1.4378 mL | 3.5945 mL | |
| 25 mM | 0.1150 mL | 0.5751 mL | 1.1503 mL | 2.8756 mL | |
| 30 mM | 0.0959 mL | 0.4793 mL | 0.9585 mL | 2.3964 mL | |
| 40 mM | 0.0719 mL | 0.3595 mL | 0.7189 mL | 1.7973 mL | |
| 50 mM | 0.0575 mL | 0.2876 mL | 0.5751 mL | 1.4378 mL | |
| 60 mM | 0.0479 mL | 0.2396 mL | 0.4793 mL | 1.1982 mL | |
| 80 mM | 0.0359 mL | 0.1797 mL | 0.3595 mL | 0.8986 mL | |
| 100 mM | 0.0288 mL | 0.1438 mL | 0.2876 mL | 0.7189 mL |
Thalidomide-5-propargyne-NH2 hydrochloride Related Classifications
HY-139546 Related Classifications
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