Thalidomide-5-propargyne-NH2 hydrochloride

Name: Thalidomide-5-propargyne-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-139546
Rating: 4.5 (1 reviews)

Cat. No.: HY-139546 Purity: 98.03%: Data Sheet
COA

SDS
Handling Instructions
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Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

Thalidomide-5-propargyne-NH2 hydrochloride Chemical Structure

CAS No. : 2490402-62-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

347.75

Formula

C₁₆H₁₄ClN₃O₄

CAS No.

2490402-62-3

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1C2=CC=C(C=C2C(N1C3C(NC(CC3)=O)=O)=O)C#CCN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (239.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8756 mL	14.3781 mL	28.7563 mL
5 mM	0.5751 mL	2.8756 mL	5.7513 mL
10 mM	0.2876 mL	1.4378 mL	2.8756 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (270 KB) SDS (394 KB)

COA (248 KB) HNMR (291 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8756 mL	14.3781 mL	28.7563 mL	71.8907 mL
	5 mM	0.5751 mL	2.8756 mL	5.7513 mL	14.3781 mL
	10 mM	0.2876 mL	1.4378 mL	2.8756 mL	7.1891 mL
	15 mM	0.1917 mL	0.9585 mL	1.9171 mL	4.7927 mL
	20 mM	0.1438 mL	0.7189 mL	1.4378 mL	3.5945 mL
	25 mM	0.1150 mL	0.5751 mL	1.1503 mL	2.8756 mL
	30 mM	0.0959 mL	0.4793 mL	0.9585 mL	2.3964 mL
	40 mM	0.0719 mL	0.3595 mL	0.7189 mL	1.7973 mL
	50 mM	0.0575 mL	0.2876 mL	0.5751 mL	1.4378 mL
	60 mM	0.0479 mL	0.2396 mL	0.4793 mL	1.1982 mL
	80 mM	0.0359 mL	0.1797 mL	0.3595 mL	0.8986 mL
	100 mM	0.0288 mL	0.1438 mL	0.2876 mL	0.7189 mL