1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-amido-C1-Br

Pomalidomide-amido-C1-Br 

Cat. No.: HY-130617
Handling Instructions

Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity.

For research use only. We do not sell to patients.

Pomalidomide-amido-C1-Br Chemical Structure

Pomalidomide-amido-C1-Br Chemical Structure

CAS No. : 2351106-38-0

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Description

Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1].

IC50 & Target

Cereblon

 

In Vitro

Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf[1].

Molecular Weight

394.18

Formula

C₁₅H₁₂BrN₃O₅

CAS No.

2351106-38-0

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CBr

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pomalidomide-amido-C1-BrE3 Ligase Ligand-Linker ConjugatePomalidomidecereblonPROTACdegraderB-RafInhibitorinhibitorinhibit

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Pomalidomide-amido-C1-Br
Cat. No.:
HY-130617
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