1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 12; E3 Ligase Ligand-Linker Conjugates 23)

Cat. No.: HY-112600
Handling Instructions

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 Chemical Structure

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 Chemical Structure

CAS No. : 2435572-48-6

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Description

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

534.56

Formula

C₂₅H₃₄N₄O₉

CAS No.
SMILES

O=C(NCCOCCCOCCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2Cereblon Ligand-Linker Conjugates 12 E3 Ligase Ligand-Linker Conjugates 23E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Cat. No.:
HY-112600
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