2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA  (Synonyms: Cereblon Ligand-Linker Conjugates 12 TFA; E3 Ligase Ligand-Linker Conjugates 23 TFA)

Cat. No.: HY-112600A Purity: 99.28%
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Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA Chemical Structure

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA Chemical Structure

CAS No. : 2435572-49-7

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Other Forms of Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA:

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA Related Antibodies

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Description

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

 

Molecular Weight

648.58

Formula

C27H35F3N4O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C(F)(F)F)=O.O=C(NCCOCCCOCCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
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Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH22435572-49-7Cereblon Ligand-Linker Conjugates 12E3 Ligase Ligand-Linker Conjugates 23E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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