Pomalidomide-amino-PEG3-NH2 hydrochloride
Based on 1 Customer Validation
Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity : 99.45%
- CAS No.: 2380273-75-4
- Formula: C21H27ClN4O8
- Molecular Weight:498.91
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2380273-75-4
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Appearance Solid
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Molecular Weight 498.91
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Formula C21H27ClN4O8
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Color White to off-white
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SMILES
[H]Cl.O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (200.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0044 mL | 10.0218 mL | 20.0437 mL | 50.1092 mL |
| 5 mM | 0.4009 mL | 2.0044 mL | 4.0087 mL | 10.0218 mL | |
| 10 mM | 0.2004 mL | 1.0022 mL | 2.0044 mL | 5.0109 mL | |
| 15 mM | 0.1336 mL | 0.6681 mL | 1.3362 mL | 3.3406 mL | |
| 20 mM | 0.1002 mL | 0.5011 mL | 1.0022 mL | 2.5055 mL | |
| 25 mM | 0.0802 mL | 0.4009 mL | 0.8017 mL | 2.0044 mL | |
| 30 mM | 0.0668 mL | 0.3341 mL | 0.6681 mL | 1.6703 mL | |
| 40 mM | 0.0501 mL | 0.2505 mL | 0.5011 mL | 1.2527 mL | |
| 50 mM | 0.0401 mL | 0.2004 mL | 0.4009 mL | 1.0022 mL | |
| 60 mM | 0.0334 mL | 0.1670 mL | 0.3341 mL | 0.8352 mL | |
| 80 mM | 0.0251 mL | 0.1253 mL | 0.2505 mL | 0.6264 mL | |
| 100 mM | 0.0200 mL | 0.1002 mL | 0.2004 mL | 0.5011 mL |
Pomalidomide-amino-PEG3-NH2 hydrochloride Related Classifications
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