Pomalidomide-PEG1-NH2 hydrochloride

Cat. No.: HY-136772 Purity: 97.05%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand.

For research use only. We do not sell to patients.

Pomalidomide-PEG1-NH2 hydrochloride Chemical Structure

CAS No. : 2380273-67-4

Size	Price	Stock	Quantity
5 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

410.81

Formula

C₁₇H₁₉ClN₄O₆

CAS No.

2380273-67-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.NCCOCC(NC1=CC=CC(C2=O)=C1C(N2C(C3=O)CCC(N3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (152.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4342 mL	12.1711 mL	24.3422 mL
5 mM	0.4868 mL	2.4342 mL	4.8684 mL
10 mM	0.2434 mL	1.2171 mL	2.4342 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.05%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (251 KB) HNMR (270 KB) RP-HPLC (205 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Lee B, et al. Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug. J Enzyme Inhib Med Chem. 2023 Dec;38(1):51-66. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4342 mL	12.1711 mL	24.3422 mL	60.8554 mL
	5 mM	0.4868 mL	2.4342 mL	4.8684 mL	12.1711 mL
	10 mM	0.2434 mL	1.2171 mL	2.4342 mL	6.0855 mL
	15 mM	0.1623 mL	0.8114 mL	1.6228 mL	4.0570 mL
	20 mM	0.1217 mL	0.6086 mL	1.2171 mL	3.0428 mL
	25 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL
	30 mM	0.0811 mL	0.4057 mL	0.8114 mL	2.0285 mL
	40 mM	0.0609 mL	0.3043 mL	0.6086 mL	1.5214 mL
	50 mM	0.0487 mL	0.2434 mL	0.4868 mL	1.2171 mL
	60 mM	0.0406 mL	0.2029 mL	0.4057 mL	1.0143 mL
	80 mM	0.0304 mL	0.1521 mL	0.3043 mL	0.7607 mL
	100 mM	0.0243 mL	0.1217 mL	0.2434 mL	0.6086 mL