1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride 

Cat. No.: HY-130682
Handling Instructions

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312).

For research use only. We do not sell to patients.

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Chemical Structure

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Chemical Structure

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Description

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)[1].

IC50 & Target

Cereblon

 

Molecular Weight

480.94

Formula

C₂₅H₂₅ClN₄O₄

SMILES

O=C1C2=C(CN1C3C(NC(CC3)=O)=O)C(C#CCCCNC(C4=CC=C(C=C4)N)=O)=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lenalidomide-propargyl-C2-amido-Ph-NH2E3 Ligase Ligand-Linker ConjugateCRBNPROTACE3ubiquitinligaselinkerInhibitorinhibitorinhibit

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Product name:
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride
Cat. No.:
HY-130682
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