2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-C12-NH2 hydrochloride

Pomalidomide-C12-NH2 hydrochloride 

Cat. No.: HY-145615 Purity: 97.09%
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Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader.

For research use only. We do not sell to patients.

Pomalidomide-C12-NH2 hydrochloride Chemical Structure

Pomalidomide-C12-NH2 hydrochloride Chemical Structure

CAS No. : 2862774-02-3

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Based on 1 publication(s) in Google Scholar

Pomalidomide-C12-NH2 hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader[1].

IC50 & Target

Cereblon

 

Molecular Weight

493.04

Formula

C25H37ClN4O4
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

NCCCCCCCCCCCCNC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Pomalidomide-C12-NH2 hydrochloride Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C12-NH22862774-02-3E3 Ligase Ligand-Linker ConjugatesKRASG12CInhibitorinhibitorinhibit

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