PROTAC KRAS G12C degrader-1
Based on 1 Customer Validation
PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells.
(Pink: KRas G12C ligand (HY-151014); Blue: Cereblon ligand (HY-10984); Black: linker (HY-W014883)).
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 2984236-79-3
- Formula: C50H54ClFN8O6
- Molecular Weight:917.47
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cereblon |
KRas G12C |
PROTAC KRAS G12C degrader-1 (Compound 10) engages CRBN in cells, bound KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in reporter cells in a CRBN-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2984236-79-3
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Appearance Solid
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Molecular Weight 917.47
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Formula C50H54ClFN8O6
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Color Light yellow to green yellow
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SMILES
OC1=CC2=C(C(C3=C(C4=C(C=C3Cl)C(N5CCN(CC5)C(C=C)=O)=NC(NCCCCCCCCCCCCNC6=C(C7=CC=C6)C(N(C7=O)C8CCC(NC8=O)=O)=O)=N4)F)=C1)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (109.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0900 mL | 5.4498 mL | 10.8995 mL | 27.2488 mL |
| 5 mM | 0.2180 mL | 1.0900 mL | 2.1799 mL | 5.4498 mL | |
| 10 mM | 0.1090 mL | 0.5450 mL | 1.0900 mL | 2.7249 mL | |
| 15 mM | 0.0727 mL | 0.3633 mL | 0.7266 mL | 1.8166 mL | |
| 20 mM | 0.0545 mL | 0.2725 mL | 0.5450 mL | 1.3624 mL | |
| 25 mM | 0.0436 mL | 0.2180 mL | 0.4360 mL | 1.0900 mL | |
| 30 mM | 0.0363 mL | 0.1817 mL | 0.3633 mL | 0.9083 mL | |
| 40 mM | 0.0272 mL | 0.1362 mL | 0.2725 mL | 0.6812 mL | |
| 50 mM | 0.0218 mL | 0.1090 mL | 0.2180 mL | 0.5450 mL | |
| 60 mM | 0.0182 mL | 0.0908 mL | 0.1817 mL | 0.4541 mL | |
| 80 mM | 0.0136 mL | 0.0681 mL | 0.1362 mL | 0.3406 mL | |
| 100 mM | 0.0109 mL | 0.0545 mL | 0.1090 mL | 0.2725 mL |
PROTAC KRAS G12C degrader-1 Related Classifications
HY-139186 Related Classifications
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