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PROTAC KRAS G12C degrader-1 

Cat. No.: HY-139186
Handling Instructions

PROTAC KRAS G12C degrader-1 is a PROTAC-based KRASG12C degrader, with an IC50 of 414 nM for CRBN. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells.

For research use only. We do not sell to patients.

PROTAC KRAS G12C degrader-1 Chemical Structure

PROTAC KRAS G12C degrader-1 Chemical Structure

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Description

PROTAC KRAS G12C degrader-1 is a PROTAC-based KRASG12C degrader, with an IC50 of 414 nM for CRBN. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1].

In Vitro

PROTAC KRAS G12C degrader-1 (Compound 12) engages CRBN in cells, bound KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in reporter cells in a CRBN-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

917.47

Formula

C₅₀H₅₄ClFN₈O₆

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
PROTAC KRAS G12C degrader-1
Cat. No.:
HY-139186
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