2984236-79-3
Chemical Structure
PROTAC KRAS G12C degrader-1
- CAS No.: 2984236-79-3
- Formula:C50H54ClFN8O6
- Molecular Weight:917.47
IUPAC Name: 4-((12-((4-(4-acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)dodecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIKey: FMYAMLPDKZOVMB-UHFFFAOYSA-N
SMILES: OC1=CC2=C(C(C3=C(C4=C(C=C3Cl)C(N5CCN(CC5)C(C=C)=O)=NC(NCCCCCCCCCCCCNC6=C(C7=CC=C6)C(N(C7=O)C8CCC(NC8=O)=O)=O)=N4)F)=C1)C=CC=C2
Biological Activity: PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC KRAS G12C degrader-1 | 99.15% | PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells. | ||||||||||||||||||||
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Keywords
