PROTAC KRAS G12C degrader-2
Based on 1 Customer Validation
PROTAC KRAS G12C (Compound 432) degrader-2 is a PROTAC degrader that targets KRASG12C by recruiting cereblon. PROTAC KRAS G12C degrader-2 covalently modifies KRASG12C. PROTAC KRAS G12C degrader-2 can be used for the research of non-small cell lung cancer.
(Pink: KRas G12C ligand (HY-175583); Blue: Cereblon ligand (HY-23095); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.45%
- CAS 番号: 2378257-72-6
- 分子式: C51H53ClFN9O7
- 分子量:958.47
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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KRASG12C |
PROTAC KRAS G12C degrader-2 (Compound 432) (0.1, 0.3, and 1 μM; 72 h) induces less than 35% KRAS degradation in homozygous KRASG12C SW1573 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW1573 cells; homozygous KRAS G12C
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Concentration:0.1, 0.3, 1 μM
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Incubation Time:72 h
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Result:Produced less than 35% KRAS degradation at each concentration.
化学情報
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CAS 番号 2378257-72-6
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性状 Solid
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分子量 958.47
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分子式 C51H53ClFN9O7
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Color Light yellow to yellow
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SMILES
FC1=C(C2=CC(O)=CC3=C2C=CC=C3)C(Cl)=CC4=C1N=C(O[C@H](C)CN5CCN(CC5)CC6CCN(C7=CC=C(C(N(C8C(NC(CC8)=O)=O)C9=O)=O)C9=C7)CC6)N=C4N%10CCN(CC%10)C(C=C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 50 mg/mL (52.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0433 mL | 5.2166 mL | 10.4333 mL | 26.0832 mL |
| 5 mM | 0.2087 mL | 1.0433 mL | 2.0867 mL | 5.2166 mL | |
| 10 mM | 0.1043 mL | 0.5217 mL | 1.0433 mL | 2.6083 mL | |
| 15 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7389 mL | |
| 20 mM | 0.0522 mL | 0.2608 mL | 0.5217 mL | 1.3042 mL | |
| 25 mM | 0.0417 mL | 0.2087 mL | 0.4173 mL | 1.0433 mL | |
| 30 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8694 mL | |
| 40 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6521 mL | |
| 50 mM | 0.0209 mL | 0.1043 mL | 0.2087 mL | 0.5217 mL |
PROTAC KRAS G12C degrader-2 関連分類
HY-153821 関連分類
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