PROTAC KRAS G12C degrader-2
Based on 1 Customer Validation
PROTAC KRAS G12C (Compound 432) degrader-2 is a PROTAC degrader that targets KRASG12C by recruiting cereblon. PROTAC KRAS G12C degrader-2 covalently modifies KRASG12C. PROTAC KRAS G12C degrader-2 can be used for the research of non-small cell lung cancer.
(Pink: KRas G12C ligand (HY-175583); Blue: Cereblon ligand (HY-23095); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 2378257-72-6
- Formula: C51H53ClFN9O7
- Molecular Weight:958.47
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
KRASG12C |
In Vitro
PROTAC KRAS G12C degrader-2 (Compound 432) (0.1, 0.3, and 1 μM; 72 h) induces less than 35% KRAS degradation in homozygous KRASG12C SW1573 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW1573 cells; homozygous KRAS G12C
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Concentration:0.1, 0.3, 1 μM
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Incubation Time:72 h
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Result:Produced less than 35% KRAS degradation at each concentration.
Chemical Information
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CAS No. 2378257-72-6
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Appearance Solid
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Molecular Weight 958.47
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Formula C51H53ClFN9O7
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Color Light yellow to yellow
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SMILES
FC1=C(C2=CC(O)=CC3=C2C=CC=C3)C(Cl)=CC4=C1N=C(O[C@H](C)CN5CCN(CC5)CC6CCN(C7=CC=C(C(N(C8C(NC(CC8)=O)=O)C9=O)=O)C9=C7)CC6)N=C4N%10CCN(CC%10)C(C=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (52.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0433 mL | 5.2166 mL | 10.4333 mL | 26.0832 mL |
| 5 mM | 0.2087 mL | 1.0433 mL | 2.0867 mL | 5.2166 mL | |
| 10 mM | 0.1043 mL | 0.5217 mL | 1.0433 mL | 2.6083 mL | |
| 15 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7389 mL | |
| 20 mM | 0.0522 mL | 0.2608 mL | 0.5217 mL | 1.3042 mL | |
| 25 mM | 0.0417 mL | 0.2087 mL | 0.4173 mL | 1.0433 mL | |
| 30 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8694 mL | |
| 40 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6521 mL | |
| 50 mM | 0.0209 mL | 0.1043 mL | 0.2087 mL | 0.5217 mL |
PROTAC KRAS G12C degrader-2 Related Classifications
HY-153821 Related Classifications
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