country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-175583

Copy Link Print Information

KRASG12C ligand-2

KRASG12C ligand-2 is a KRas ligand used for PROTAC synthesis. KRASG12C ligand-2 serves as the target protein ligand of PROTAC KRAS G12C degrader-2 (HY-153821).

For research use only. We do not sell to patients.

CAS No.: 2725905-93-9
Formula: C₂₈H₂₄ClFN₄O₄
Molecular Weight:534.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRASG12C ligand-2 Chemical Structure

CAS No.: 2725905-93-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRASG12C ligand-2 is a KRas ligand used for PROTAC synthesis. KRASG12C ligand-2 serves as the target protein ligand of PROTAC KRAS G12C degrader-2 (HY-153821)^[1].

IC₅₀ & Target^[1]

KRas G12C

All Ras Isoforms :

In Vitro

KRASG12C ligand-2 serves as the target protein ligand for PROTAC KRAS G12C degrader-2 (HY-153821). PROTAC KRAS G12C degrader-2 (compound 432) is a K-Ras proteolytic modulator and a bifunctional compound^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2725905-93-9
Molecular Weight 534.97
Formula C₂₈H₂₄ClFN₄O₄
SMILES

FC1=C(C2=CC(O)=CC3=C2C=CC=C3)C(Cl)=CC4=C1N=C(O[C@H](C)C=O)N=C4N5CCN(CC5)C(C=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Crew Andrew, et al.. Preparation of bifunctional compounds as modulators of proteolysis useful for treating cancer. World Intellectual Property Organization, WO2019195609 A2. 2019-10-10.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

KRASG12C ligand-2

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRASG12C ligand-2 Related Classifications

HY-175583 Related Classifications