2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. SK-575-NEG

SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM.

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SK-575-NEG Chemical Structure

SK-575-NEG Chemical Structure

CAS No. : 2523017-04-9

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Based on 1 publication(s) in Google Scholar

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Description

SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM[1].

IC50 & Target

PARP-1

2.64 nM (IC50)

Molecular Weight

891.00

Formula

C48H55FN8O8
CAS No.
SMILES

O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCCCCCCC(NCCNC4=CC=CC(C(N5C6C(N(C)C(CC6)=O)=O)=O)=C4C5=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7
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Purity & Documentation
References
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SK-575-NEG Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK-575-NEG2523017-04-9PARPpoly ADP ribose polymeraseMDA-MB-436 cellCapan-1 cellsPARP1 degraderPROTACtumorInhibitorinhibitorinhibit

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