SK-575-NEG
SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM.
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- CAS No.: 2523017-04-9
- 화학식: C48H55FN8O8
- 분자량:891.00
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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PARP-1 2.64 nM (IC50) |
Chemical Information
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CAS No. 2523017-04-9
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분자량 891.00
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화학식 C48H55FN8O8
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SMILES
O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCCCCCCC(NCCNC4=CC=CC(C(N5C6C(N(C)C(CC6)=O)=O)=O)=C4C5=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SK-575-NEG Related Classifications
HY-147101 Related Classifications
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