2523017-04-9
Chemical Structure
SK-575-NEG
- CAS No.: 2523017-04-9
- Formula:C48H55FN8O8
- Molecular Weight:891.00
IUPAC Name: 12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-N-(2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-oxododecanamide
InChIKey: BFHBWQUTCXAXMP-UHFFFAOYSA-N
SMILES: O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCCCCCCC(NCCNC4=CC=CC(C(N5C6C(N(C)C(CC6)=O)=O)=O)=C4C5=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7
Biological Activity: SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM[1].
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SK-575-NEG | SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM. | |||||||||||||||||||||
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Keywords
