PROTAC FSP1 degrader 1

PROTAC FSP1 degrader 1 (Compound 2307) (0-2 μM, 24 h) achieves an 83.2% degradation rate of FSP1 protein (DC₅₀ = 263.7 nM) with no hook effect and demonstrates concentration-dependent degradation in MDA-MB-231 cells^[1].
PROTAC FSP1 degrader 1 (1 μM, 24 h)-mediated degradation of FSP1 is significantly inhibited by pretreatment with MG132 (HY-13259), Pevonedistat (MLN4924) (HY-70062), and Pomalidomide (HY-10984) in MDA-MB-231 cells^[1].
PROTAC FSP1 degrader 1 (0-100 μM, 24-48 h) does not show significant cytotoxicity against MDA-MB-231 cells when used alone (no significant decrease in cell viability), but it synergistically enhances cell death when used in combination with the GPX4 inhibitor RSL3^[1].
PROTAC FSP1 degrader 1 (10 μM, 24 h) significantly reduces the proportion of EdU-positive cells and inhibits the proliferation of MDA-MB-231 cells^[1].
PROTAC FSP1 degrader 1 (10 μM, 24 h) can induce the accumulation of ROS in MDA-MB-231 cells, initiating lipid peroxidation and ferroptosis^[1].
PROTAC FSP1 degrader 1 (10 μM, 24 h) induces lipid peroxidation in MDA-MB-231 cells by degrading FSP1, a process that could be reversed by Fer-1, confirming the ferroptosis pathway^[1].
PROTAC FSP1 degrader 1 (0.2-5 μM, 24 h) upregulates the mRNA expression of ferroptosis-related genes (GPX4, FTH1, ACSL4, TfR1, FSP1) in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.