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iFSP1

32 Cited Publications
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Based on 32 publication(s) in Google Scholar

iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A).

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  • Purity: 99.96%
  • CAS No.: 150651-39-1
  • Formula: C20H13N5
  • Molecular Weight:323.35
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • iFSP1 Chemical Structure
    iFSP1 Chemical Structure
  • Experimental Validation Results for iFSP1
  • Experimental Validation Results for iFSP1
  • Experimental Validation Results for iFSP1
  • Experimental Validation Results for iFSP1
  • Experimental Validation Results for iFSP1
CAS No.: 150651-39-1
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Cell Proliferation/Viability AssayIn Vivo Efficacy StudyWB
  • Cell Proliferation/Viability Assay
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  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
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  • iFSP1 Chemical Structure
    iFSP1 Chemical Structure
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    iFSP1 purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8096):477-486. [Abstract]

    Customer Validation
     Cell viability of A-375 cells ± iFSP1 (10 μM) ± BSO (1 mM) or combinations for 48 h.

  • 1/16

    iFSP1 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec;12(46):e04245. [Abstract]

    Customer Validation
     Schematic representation of the experimental induction of trained immunity in CIA treated with iFSP1 (10.0 mg kg−1 daily), Arthritis index and paw thickness were scored and compared with CIA. the establishment of a trained immunity model (β‐glucan or PBS) was initiated on day 0, the establishment of a CIA rat model was initiated on day 7, CIA was re‐enforced on day 14, and ferroptosis induction was initiated by daily intraperitoneal injection of iFSP1 (10.0 mg/kg/ daily) on day 14, the experiment was terminated on day 35.

  • 1/16

    iFSP1 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec;12(46):e04245. [Abstract]

    Customer Validation
     Representative photographs of morphology in different groups, H&E, toluidine blue O, and safranin O staining of representative joints in different groups. the establishment of a trained immunity model (β‐glucan or PBS) was initiated on day 0, the establishment of a CIA rat model was initiated on day 7, CIA was re‐enforced on day 14, and ferroptosis induction was initiated by daily intraperitoneal injection of iFSP1 (10.0 mg/kg/ daily) on day 14, the experiment was terminated on day 35.

  • 1/16

    iFSP1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Oct 30;14(1):6908. [Abstract]

    Customer Validation
     Ferroptosis inhibition by FXR activation is reverted when FSP1 or PPARα are inhibited. Ferroptosis was induced by 200 nM RSL3 for 18 h, 12 µM Turofexorate was used to inhibit ferroptosis. FSP1 was inhibited by iFSP1 (0.2, 1.5, 6.3, 25 μM), PPARα was inhibited by GW6471 (PPARαi).

  • 1/16

    iFSP1 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 May 3;8(1):40. [Abstract]

    Customer Validation
     U2OS cells were treated with iFSP1 (10 µM; 0, 0.5, 1, 2, 4, 8 h). O-GlcNAcylation levels were detected by immunoblotting with antibodies against O-GlcNAc and β-actin, and the relative intensity (O-GlcNAc/b-actin) was quantified.

  • iFSP1