1. Apoptosis
  2. Ferroptosis
  3. Imidazole ketone erastin

Imidazole ketone erastin (Synonyms: IKE)

Cat. No.: HY-114481 Purity: 99.67%
Handling Instructions

Imidazole ketone erastin (IKE) is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.

For research use only. We do not sell to patients.

Imidazole ketone erastin Chemical Structure

Imidazole ketone erastin Chemical Structure

CAS No. : 1801530-11-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 360 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Imidazole ketone erastin:

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Description

Imidazole ketone erastin (IKE) is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.

IC50 & Target

System Xc-, ferroptosis[1]

Molecular Weight

655.14

Formula

C₃₅H₃₅ClN₆O₅

CAS No.

1801530-11-9

SMILES

O=C1N(C2=CC(C(CN3C=CN=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (190.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5264 mL 7.6320 mL 15.2639 mL
5 mM 0.3053 mL 1.5264 mL 3.0528 mL
10 mM 0.1526 mL 0.7632 mL 1.5264 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.67%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Imidazole ketone erastin
Cat. No.:
HY-114481
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