2. Apoptosis
  3. Ferroptosis
  4. FINO2

FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation.

For research use only. We do not sell to patients.

CAS No. : 869298-31-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 12 publication(s) in Google Scholar

FINO2 Related Antibodies

Top Publications Citing Use of Products

    FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845.  [Abstract]

    Lipid peroxidation of FSP1‐depleted HCT116 cells treated with FINO2 (20 µM) for 12 h.

    FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845.  [Abstract]

    HCT116 cells death of HCT116 cells treated with SAHA and FINO2 (20 µm) for 24 h.

    FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845.  [Abstract]

    Cell death (detected at 24 h) of HCT116 cells treated with different FINs (RSL3: 5 µM, erastin: 40 µM, FINO2: 20 µM).

    FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845.  [Abstract]

    lipid peroxidation (detected at 12 h) of HCT116 cells treated with different FINs (RSL3: 5 µM, erastin: 40 µM, FINO2: 20 µM).

    FINO2 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 May 3;43(1):133.  [Abstract]

    Viability of FCN3- and nsFCN3-overexpressed MHCC97-H cells treated with indicated concentrations of FINO2 (0-6 μM) for 24 h.

    FINO2 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 May 3;43(1):133.  [Abstract]

    Representative images of nsFCN3-overexpressed YY-8103 cells treated with FINO2 (10 µM) and Ferr-1 (2 µM). Scale bar, 100 μm.

    FINO2 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 May 3;43(1):133.  [Abstract]

    Representative images of nsFCN3-overexpressed YY-8103 cells treated with FINO2 (10 µM) and NAC (1 mM). Scale bar, 100 μm.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1].

    In Vitro

    FINO2 (10 μM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    FINO2 Related Antibodies
    Molecular Weight

    256.38

    Formula

    C15H28O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OCCC1(C[C@](CC[C@H]2C(C)(C)C)(CC2)OO1)C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (195.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9005 mL 19.5023 mL 39.0046 mL
    5 mM 0.7801 mL 3.9005 mL 7.8009 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.0%

    SDS (251 KB)

    COA (245 KB) HNMR (158 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.9005 mL 19.5023 mL 39.0046 mL 97.5115 mL
    5 mM 0.7801 mL 3.9005 mL 7.8009 mL 19.5023 mL
    10 mM 0.3900 mL 1.9502 mL 3.9005 mL 9.7512 mL
    15 mM 0.2600 mL 1.3002 mL 2.6003 mL 6.5008 mL
    20 mM 0.1950 mL 0.9751 mL 1.9502 mL 4.8756 mL
    25 mM 0.1560 mL 0.7801 mL 1.5602 mL 3.9005 mL
    30 mM 0.1300 mL 0.6501 mL 1.3002 mL 3.2504 mL
    40 mM 0.0975 mL 0.4876 mL 0.9751 mL 2.4378 mL
    50 mM 0.0780 mL 0.3900 mL 0.7801 mL 1.9502 mL
    60 mM 0.0650 mL 0.3250 mL 0.6501 mL 1.6252 mL
    80 mM 0.0488 mL 0.2438 mL 0.4876 mL 1.2189 mL
    100 mM 0.0390 mL 0.1950 mL 0.3900 mL 0.9751 mL
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    FINO2 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    FINO2869298-31-7FINO 2FINO-2FerroptosisHT-1080 cellsGPX4peroxidationoxidizes ironInhibitorinhibitorinhibit

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