1. Metabolic Enzyme/Protease
    Apoptosis
  2. Glutathione Peroxidase
    Ferroptosis
  3. ML-210

ML-210 

Cat. No.: HY-100003 Purity: 98.64%
Handling Instructions

ML-210,the most potent compound in the nitroisoxazole series, is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively.

For research use only. We do not sell to patients.

ML-210 Chemical Structure

ML-210 Chemical Structure

CAS No. : 1360705-96-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 97 In-stock
Estimated Time of Arrival: December 31
5 mg USD 93 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ML-210,the most potent compound in the nitroisoxazole series, is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].

IC50 & Target

Glutathione Peroxidase 4 (GPX4)[1]

Molecular Weight

475.32

Formula

C₂₂H₂₀Cl₂N₄O₄

CAS No.

1360705-96-9

SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

ML-210ML210ML 210Glutathione PeroxidaseFerroptosisInhibitorinhibitorinhibit

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