1. Metabolic Enzyme/Protease
  2. Glutathione Peroxidase
  3. ML-210

ML-210 

Cat. No.: HY-100003
Handling Instructions

ML-210,the most potent compound in the nitroisoxazole series, is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively.

For research use only. We do not sell to patients.

ML-210 Chemical Structure

ML-210 Chemical Structure

CAS No. : 1360705-96-9

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Description

ML-210,the most potent compound in the nitroisoxazole series, is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].

IC50 & Target

Glutathione Peroxidase 4 (GPX4)[1]

Molecular Weight

475.32

Formula

C₂₂H₂₀Cl₂N₄O₄

CAS No.

1360705-96-9

SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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