1360705-96-9
1360705-96-9
Chemical Structure
ML-210
- CAS No.: 1360705-96-9
- Formula:C22H20Cl2N4O4
- Molecular Weight:475.32
IUPAC Name: (4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
InChIKey: VIBHJPDPEVVDTB-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
Biological Activity: ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2].
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ML-210 | 99.93% | ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity. | ||||||||||||||||||||
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ML-210 (Standard) | ≥98% | ML-210 (Standard) is the analytical standard of ML-210 (HY-100003). This product is intended for research and analytical applications. ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity. | ||||||||||||||||||||
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References
- [1]. John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018.
- [2]. Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. [Content Brief]
