1. Metabolic Enzyme/Protease
    Apoptosis
  2. Glutathione Peroxidase
    Ferroptosis
  3. GPX4-IN-3

GPX4-IN-3 

Cat. No.: HY-141809 Purity: 99.69%
Handling Instructions

GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.

For research use only. We do not sell to patients.

GPX4-IN-3 Chemical Structure

GPX4-IN-3 Chemical Structure

Size Price Stock Quantity
5 mg USD 390 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM[1].

In Vitro

GPX4-IN-3 (26a) exhibits IC50 values of 0.78 μM, 6.9 μM, 0.15 μM and 4.73 μM in 4T1, MCF-7, HT1080 and HT1080 (with Fer-1) cells, respectively[1].
GPX4-IN-3 (26a) exhibits outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3[1].
GPX4-IN-3 (26a) could significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity[1].
GPX4-IN-3 (26a) is more likely to induce ferroptosis through the accumulation of intracellular peroxides via inhibiting GPX4 activity[1].
GPX4-IN-3 (26a) significantly increased the level of ROS in 4T1 cells, which could also be reversed by Ferrostatin-1 (fer-1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GPX4-IN-3 (26a) exertes antitumor activity and good biological safety in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse 4T1 xenograft model[1].
Dosage: 15 and 30 mg/kg.
Administration: Intravenous injection, every two days for a total of five times.
Result: Significantly suppress tumor growth with a tumor growth inhibition (TGI) value of 33.2 and 55.1% at 15 and 30 mg/kg, respectively.
Molecular Weight

530.04

Formula

C₂₉H₂₄ClN₃O₃S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 67.5 mg/mL (127.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8867 mL 9.4333 mL 18.8665 mL
5 mM 0.3773 mL 1.8867 mL 3.7733 mL
10 mM 0.1887 mL 0.9433 mL 1.8867 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 6.75 mg/mL (12.73 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.75 mg/mL (12.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
GPX4-IN-3
Cat. No.:
HY-141809
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