PKUMDL-LC-101-D04
Based on 7 publication(s) in Google Scholar
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 2143896-83-5
- Formula: C14H23ClN4O2S2
- Molecular Weight:378.94
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PKUMDL-LC-101-D04
More- J Hazard Mater. 2024 Sep 15:477:135199. [Abstract]
- Cancer Lett. 2025 Apr 29:217759. [Abstract]
- Int J Biol Macromol. 2025 May 14:144242. [Abstract]
- Biomed Pharmacother. 2023 Nov:167:115547. [Abstract]
- Int J Mol Med. 2025 Apr;55(4):64. [Abstract]
- Brain Res Bull. 2026 Apr:237:111804. [Abstract]
- Biochem Biophys Res Commun. 2026 Feb 12:800:153270. [Abstract]
Biological Activity
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GPX4 |
PKUMDL-LC-101-D04 (20 μM) increases the activity of GPX4 by 150% in cell-free experiments[1].
PKUMDL-LC-101-D04 (61 μM) boosted GPX4 activity to 150% in mouse embryonic fibroblast (MEF) cell extracts[1].
PKUMDL-LC-101-D04 (0-150 μM) activates GPX4 in cells and protects against the toxic effects of cholesterol peroxide[1].
PKUMDL-LC-101-D04 (200 μM,1 h) can inhibit cell death induced by cholesterol peroxide, which is a specific substrate of GPX4[1].
PKUMDL-LC-101-D04 (65 μM, 24 h) does not reduce ROS production in 661 W cells[2].
PKUMDL-LC-101-D04 significantly increased the levels of MDA and iron ions in 661 W cells while reducing mitochondrial shrinkage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2143896-83-5
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Appearance Solid
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Molecular Weight 378.94
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Formula C14H23ClN4O2S2
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Color White to off-white
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SMILES
O=S(C1=CC=C(NC(NC2CCCC2)=S)C=C1)(NCCN)=O.[H]Cl
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Synonyms
GPX4-Activator-1d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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J Hazard Mater
Systematic health risks assessment of chiral fungicide famoxadone: Stereoselectivities in ferroptosis-mediated cytotoxicity and metabolic behavior. [Abstract]2024 Sep 15:477:135199. PMID: 39053069 -
Cancer Lett
Sonrotoclax (BGB-11417) synergistically amplifies the radiotherapy-elicited anti-tumor immune response. [Abstract]2025 Apr 29:217759. PMID: 40311913 -
Int J Biol Macromol
A novel peptide TCL6148 induces ferroptosis via the GOT1/GPX4 pathway to enhance sunitinib sensitivity in renal cell carcinoma. [Abstract]2025 May 14:144242. PMID: 40379184 -
Biomed Pharmacother
Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa. [Abstract]2023 Nov:167:115547. PMID: 37741257 -
Int J Mol Med
p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke. [Abstract]2025 Apr;55(4):64. PMID: 39981897 -
Brain Res Bull
Calycosin exerts anti-glioblastoma effects by inhibiting GPX-4 to promote oxidative stress. [Abstract]2026 Apr:237:111804. PMID: 41771447 -
Biochem Biophys Res Commun
Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis. [Abstract]2026 Feb 12:800:153270. PMID: 41529459
Solvent & Solubility
DMSO : 200 mg/mL (527.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (5.49 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6389 mL | 13.1947 mL | 26.3894 mL | 65.9735 mL |
| 5 mM | 0.5278 mL | 2.6389 mL | 5.2779 mL | 13.1947 mL | |
| 10 mM | 0.2639 mL | 1.3195 mL | 2.6389 mL | 6.5974 mL | |
| 15 mM | 0.1759 mL | 0.8796 mL | 1.7593 mL | 4.3982 mL | |
| 20 mM | 0.1319 mL | 0.6597 mL | 1.3195 mL | 3.2987 mL | |
| 25 mM | 0.1056 mL | 0.5278 mL | 1.0556 mL | 2.6389 mL | |
| 30 mM | 0.0880 mL | 0.4398 mL | 0.8796 mL | 2.1991 mL | |
| 40 mM | 0.0660 mL | 0.3299 mL | 0.6597 mL | 1.6493 mL | |
| 50 mM | 0.0528 mL | 0.2639 mL | 0.5278 mL | 1.3195 mL | |
| 60 mM | 0.0440 mL | 0.2199 mL | 0.4398 mL | 1.0996 mL | |
| 80 mM | 0.0330 mL | 0.1649 mL | 0.3299 mL | 0.8247 mL | |
| 100 mM | 0.0264 mL | 0.1319 mL | 0.2639 mL | 0.6597 mL |
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