1. Apoptosis
  2. Ferroptosis
  3. FIN56

FIN56 

Cat. No.: HY-103087 Purity: 98.17%
Handling Instructions

FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase.

For research use only. We do not sell to patients.

FIN56 Chemical Structure

FIN56 Chemical Structure

CAS No. : 1083162-61-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 82 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Estimated Time of Arrival: December 31
100 mg USD 804 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

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Description

FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase[1].

In Vitro

FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4)[2].
FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: TP53+/+ and TP53-/- HCT116 cells
Concentration: 5 μM
Incubation Time:
Result: Triggered ferroptosis.

Western Blot Analysis[3]

Cell Line: HT-1080 cells
Concentration: 5 μM
Incubation Time: 10 hours
Result: Caused a large decrease in the abundance of GPX4 at the protein level.
Molecular Weight

517.66

Formula

C₂₅H₃₁N₃O₅S₂

CAS No.
SMILES

O=S(C1=CC(/C2=N\O)=C(C3=C2C=C(S(=O)(NC4CCCCC4)=O)C=C3)C=C1)(NC5CCCCC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (193.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9318 mL 9.6588 mL 19.3177 mL
5 mM 0.3864 mL 1.9318 mL 3.8635 mL
10 mM 0.1932 mL 0.9659 mL 1.9318 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (4.83 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.83 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FIN56FIN 56FIN-56FerroptosisdegradationGPX4squalenesynthaseInhibitorinhibitorinhibit

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FIN56
Cat. No.:
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