Pomalidomide-C5-Dovitinib
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia.
(Pink: c-Kit and FLT3 ligand (HY-50905); Blue: Cereblon ligand (HY-130737); Black: linker (HY-B0236)).
For research use only. We do not sell to patients.
- CAS No.: 2732969-67-2
- Formula: C39H38FN9O6
- Molecular Weight:747.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
9.5 nM
Compound: 2
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Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 34694800] |
| MV4-11 | IC50 |
9.2 nM
Compound: 2
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Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 34694800] |
Chemical Information
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CAS No. 2732969-67-2
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Molecular Weight 747.77
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Formula C39H38FN9O6
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SMILES
O=C1NC2=C(C(N)=C1C3=NC4=CC=C(N5CCN(CC5)C(CCCCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)C=C4N3)C(F)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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