2. Metabolic Enzyme/Protease PROTAC
  3. PAI-1 Plasminogen/Plasmin PROTAC Linkers
  4. 6-Aminocaproic acid

6-Aminocaproic acid  (Synonyms: EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid)

Cat. No.: HY-B0236 Purity: 99.86%
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6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

For research use only. We do not sell to patients.

CAS No. : 60-32-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of 6-Aminocaproic acid:

6-Aminocaproic acid Related Antibodies

Top Publications Citing Use of Products

    6-Aminocaproic acid purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8065):1298-1308.  [Abstract]

    Timeline for studying the role of neutrophil elastase and endogenous tPA in thromboinflammation under the 1 ng/mL TNF-α condition. Representative 3D confocal microscopy Z-stack images show that the human neutrophil elastase inhibitor BAY 85–8501 and antifibrinolytic compound 6-Aminocaproic acid (1 mM) together block fibrin degradation.

    6-Aminocaproic acid purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2023 Sep;193(9):1319-1334.  [Abstract]

    Pharmacological blockade of plasminogen-induced endothelial cell (EC) tube regression using inhibitors targeting serine proteinases and matrix metalloproteinases. Both control (Con) ECs and ECs expressing k-RasV12 were seeded in collagen matrices for 72 hours in the presence of plasminogen (PLG) (2 μg/mL) and the indicated pharmacological agents. A competitive inhibitor of plasminogen binding to cell surfaces, 6-Aminocaproic acid (EACA), was added at 100 μg/mL, a direct inhibitor of plasmin, aprotinin (Apr), was added at 1 μg/mL, and the broad spectrum MMP inhibitor, GM6001, was added at 10 μmol/L. The contraction of collagen gel was recorded and photographed.

    6-Aminocaproic acid purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2023 Sep;193(9):1319-1334.  [Abstract]

    Pharmacological blockade of plasminogen-induced endothelial cell (EC) tube regression using inhibitors targeting serine proteinases and matrix metalloproteinases. Both control (Con) ECs and ECs expressing k-RasV12 were seeded in collagen matrices for 72 hours in the presence of plasminogen (PLG) (2 μg/mL) and the indicated pharmacological agents. A competitive inhibitor of plasminogen binding to cell surfaces, 6-Aminocaproic acid (EACA), was added at 100 μg/mL, a direct inhibitor of plasmin, aprotinin (Apr), was added at 1 μg/mL, and the broad spectrum MMP inhibitor, GM6001, was added at 10 μmol/L. The conditioned medium was collected and evaluated for MMP-1 expression and activation. The conditioned media were collected at 72 hours, and Western blots were performed to assess the levels of MMP-1 zymogen and activated MMP-1.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

    In Vitro

    6-Aminocaproic acid (20-180 μg/mL) inhibits fibrinolysis in plasma of Asian elephants, with an effective concentration of 61.5 μg/mL[2].
    6-Aminocaproic acid can be used as a hydrophobic linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    6-Aminocaproic acid Related Antibodies
    In Vivo

    6-Aminocaproic acid (20-100 mg/kg; a single p.o.) inhibits fibrinolysis at all doses tested in dogs[3].
    6-Aminocaproic acid (20-100 mg/kg; a single p.o.) is rapidly absorbed (Tmax=1 h) and eliminated rapidly in dogs[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    131.17

    Formula

    C6H13NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)CCCCCN
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (381.18 mM)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.6237 mL 38.1185 mL 76.2369 mL
    5 mM 1.5247 mL 7.6237 mL 15.2474 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (190.59 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    SDS (396 KB)

    COA (240 KB) HNMR (122 KB) RP-HPLC (240 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.6237 mL 38.1185 mL 76.2369 mL 190.5924 mL
    5 mM 1.5247 mL 7.6237 mL 15.2474 mL 38.1185 mL
    10 mM 0.7624 mL 3.8118 mL 7.6237 mL 19.0592 mL
    15 mM 0.5082 mL 2.5412 mL 5.0825 mL 12.7062 mL
    20 mM 0.3812 mL 1.9059 mL 3.8118 mL 9.5296 mL
    25 mM 0.3049 mL 1.5247 mL 3.0495 mL 7.6237 mL
    30 mM 0.2541 mL 1.2706 mL 2.5412 mL 6.3531 mL
    40 mM 0.1906 mL 0.9530 mL 1.9059 mL 4.7648 mL
    50 mM 0.1525 mL 0.7624 mL 1.5247 mL 3.8118 mL
    60 mM 0.1271 mL 0.6353 mL 1.2706 mL 3.1765 mL
    80 mM 0.0953 mL 0.4765 mL 0.9530 mL 2.3824 mL
    100 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9059 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    6-Aminocaproic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    6-Aminocaproic acid60-32-2EACA Epsilon-Amino-n-caproic Acid 6-Aminohexanoic acidPAI-1Plasminogen/PlasminPROTAC LinkersPlasminogen activator inhibitor-1plasminplasminogenantifibrinolyticclotlysisfibrinolysisbleedingInhibitorinhibitorinhibit

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