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6-Aminocaproic acid (Synonyms: EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid)

Cat. No.: HY-B0236 Purity: ≥98.0%
Handling Instructions

6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

For research use only. We do not sell to patients.

6-Aminocaproic acid Chemical Structure

6-Aminocaproic acid Chemical Structure

CAS No. : 60-32-2

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Solution
10 mM * 1 mL in Water USD 73 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 96 In-stock
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Description

6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

In Vitro

6-Aminocaproic acid (20-180 μg/mL) inhibits fibrinolysis in plasma of Asian elephants, with an effective concentration of 61.5 μg/mL[2].
6-Aminocaproic acid can be used as a hydrophobic linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

6-Aminocaproic acid (20-100 mg/kg; a single p.o.) inhibits fibrinolysis at all doses tested in dogs[3].
6-Aminocaproic acid (20-100 mg/kg; a single p.o.) is rapidly absorbed (Tmax=1 h) and eliminated rapidly in dogs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

131.17

Formula

C6H13NO2

CAS No.
SMILES

O=C(O)CCCCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (381.18 mM)

DMSO : 1 mg/mL (7.62 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6237 mL 38.1185 mL 76.2369 mL
5 mM 1.5247 mL 7.6237 mL 15.2474 mL
10 mM 0.7624 mL 3.8118 mL 7.6237 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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6-Aminocaproic acid
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HY-B0236
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