6-Aminocaproic acid-d6
Based on 1 Customer Validation
6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 1228656-08-3
- Formula: C6H7D6NO2
- Molecular Weight:137.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1228656-08-3
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Unlabeled Cas 60-32-2
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Appearance Solid
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Molecular Weight 137.21
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Formula C6H7D6NO2
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Color White to off-white
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SMILES
O=C(O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])CN
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Synonyms
EACA-d6; Epsilon-Amino-n-caproic acid-d6; 6-Aminohexanoic acid-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : ≥ 50 mg/mL (364.40 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Griffin JD, et, al. Epsilon-aminocaproic acid (EACA). Semin Thromb Hemost. Summer 1978;5(1):27-40. [Content Brief]
[3]. Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS). J Zoo Wildl Med. 2016 Jun;47(2):397-404. [Content Brief]
[4]. Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77(11):1258-1265. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.2881 mL | 36.4405 mL | 72.8810 mL | 182.2025 mL |
| 5 mM | 1.4576 mL | 7.2881 mL | 14.5762 mL | 36.4405 mL | |
| 10 mM | 0.7288 mL | 3.6440 mL | 7.2881 mL | 18.2202 mL | |
| 15 mM | 0.4859 mL | 2.4294 mL | 4.8587 mL | 12.1468 mL | |
| 20 mM | 0.3644 mL | 1.8220 mL | 3.6440 mL | 9.1101 mL | |
| 25 mM | 0.2915 mL | 1.4576 mL | 2.9152 mL | 7.2881 mL | |
| 30 mM | 0.2429 mL | 1.2147 mL | 2.4294 mL | 6.0734 mL | |
| 40 mM | 0.1822 mL | 0.9110 mL | 1.8220 mL | 4.5551 mL | |
| 50 mM | 0.1458 mL | 0.7288 mL | 1.4576 mL | 3.6440 mL | |
| 60 mM | 0.1215 mL | 0.6073 mL | 1.2147 mL | 3.0367 mL | |
| 80 mM | 0.0911 mL | 0.4555 mL | 0.9110 mL | 2.2775 mL | |
| 100 mM | 0.0729 mL | 0.3644 mL | 0.7288 mL | 1.8220 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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