2. Others Metabolic Enzyme/Protease
  3. PAI-1 Drug Derivative
  4. 6-Aminocaproic acid hydrochloride

6-Aminocaproic acid hydrochloride  (Synonyms: EACA hydrochloride; Epsilon-Amino-n-caproic Acid hydrochloride; 6-Aminohexanoic acid hydrochloride)

Cat. No.: HY-B0236A
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6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

For research use only. We do not sell to patients.

CAS No. : 4321-58-8

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6-Aminocaproic acid hydrochloride Related Antibodies

Top Publications Citing Use of Products
2D/3D Cell Culture and Differentiation
Cell Imaging/Staining
WB

    6-Aminocaproic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8065):1298-1308.  [Abstract]

    Timeline for studying the role of neutrophil elastase and endogenous tPA in thromboinflammation under the 1 ng/mL TNF-α condition. Representative 3D confocal microscopy Z-stack images show that the human neutrophil elastase inhibitor BAY 85–8501 and antifibrinolytic compound 6-Aminocaproic acid (1 mM) together block fibrin degradation.

    6-Aminocaproic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2023 Sep;193(9):1319-1334.  [Abstract]

    Pharmacological blockade of plasminogen-induced endothelial cell (EC) tube regression using inhibitors targeting serine proteinases and matrix metalloproteinases. Both control (Con) ECs and ECs expressing k-RasV12 were seeded in collagen matrices for 72 hours in the presence of plasminogen (PLG) (2 μg/mL) and the indicated pharmacological agents. A competitive inhibitor of plasminogen binding to cell surfaces, 6-Aminocaproic acid (EACA), was added at 100 μg/mL, a direct inhibitor of plasmin, aprotinin (Apr), was added at 1 μg/mL, and the broad spectrum MMP inhibitor, GM6001, was added at 10 μmol/L. The contraction of collagen gel was recorded and photographed.

    6-Aminocaproic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2023 Sep;193(9):1319-1334.  [Abstract]

    Pharmacological blockade of plasminogen-induced endothelial cell (EC) tube regression using inhibitors targeting serine proteinases and matrix metalloproteinases. Both control (Con) ECs and ECs expressing k-RasV12 were seeded in collagen matrices for 72 hours in the presence of plasminogen (PLG) (2 μg/mL) and the indicated pharmacological agents. A competitive inhibitor of plasminogen binding to cell surfaces, 6-Aminocaproic acid (EACA), was added at 100 μg/mL, a direct inhibitor of plasmin, aprotinin (Apr), was added at 1 μg/mL, and the broad spectrum MMP inhibitor, GM6001, was added at 10 μmol/L. The conditioned medium was collected and evaluated for MMP-1 expression and activation. The conditioned media were collected at 72 hours, and Western blots were performed to assess the levels of MMP-1 zymogen and activated MMP-1.

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    Description

    6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

    In Vitro

    6-Aminocaproic acid hydrochloride (20-180 μg/mL) inhibits fibrinolysis in plasma of Asian elephants, with an effective concentration of 61.5 μg/mL[2].
    6-Aminocaproic acid hydrochloride can be used as a hydrophobic linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    6-Aminocaproic acid hydrochloride Related Antibodies
    In Vivo

    6-Aminocaproic acid hydrochloride (20-100 mg/kg; a single p.o.) inhibits fibrinolysis at all doses tested in dogs[3].
    6-Aminocaproic acid hydrochloride (20-100 mg/kg; a single p.o.) is rapidly absorbed (Tmax=1 h) and eliminated rapidly in dogs[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    167.63

    Formula

    C6H14ClNO2
    CAS No.
    SMILES

    O=C(O)CCCCCN.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    6-Aminocaproic acid hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    6-Aminocaproic acid4321-58-8EACAEpsilon-Amino-n-caproic Acid6-Aminohexanoic acidPAI-1Drug DerivativePlasminogen activator inhibitor-1Drug derivativeplasminplasminogenantifibrinolyticfibrinolysisbleedingInhibitorinhibitorinhibit

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