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6-Aminocaproic acid hydrochloride

(Synonyms: EACA hydrochloride; Epsilon-Amino-n-caproic Acid hydrochloride; 6-Aminohexanoic acid hydrochloride)
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Based on 4 publication(s) in Google Scholar

6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

For research use only. We do not sell to patients.

  • CAS No.: 4321-58-8
  • Formula: C6H14ClNO2
  • Molecular Weight:167.63
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • 6-Aminocaproic acid hydrochloride Chemical Structure
    6-Aminocaproic acid hydrochloride Chemical Structure
  • Experimental Validation Results for 6-Aminocaproic acid hydrochloride
  • Experimental Validation Results for 6-Aminocaproic acid hydrochloride
  • Experimental Validation Results for 6-Aminocaproic acid hydrochloride
CAS No.: 4321-58-8
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  • 6-Aminocaproic acid hydrochloride Chemical Structure
    6-Aminocaproic acid hydrochloride Chemical Structure
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    6-Aminocaproic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8065):1298-1308. [Abstract]

    Customer Validation
     Timeline for studying the role of neutrophil elastase and endogenous tPA in thromboinflammation under the 1 ng/mL TNF-α condition. Representative 3D confocal microscopy Z-stack images show that the human neutrophil elastase inhibitor BAY 85–8501 and antifibrinolytic compound 6-Aminocaproic acid (1 mM) together block fibrin degradation.

  • 1/16

    6-Aminocaproic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2023 Sep;193(9):1319-1334. [Abstract]

    Customer Validation
     Pharmacological blockade of plasminogen-induced endothelial cell (EC) tube regression using inhibitors targeting serine proteinases and matrix metalloproteinases. Both control (Con) ECs and ECs expressing k-RasV12 were seeded in collagen matrices for 72 hours in the presence of plasminogen (PLG) (2 μg/mL) and the indicated pharmacological agents. A competitive inhibitor of plasminogen binding to cell surfaces, 6-Aminocaproic acid (EACA), was added at 100 μg/mL, a direct inhibitor of plasmin, aprotinin (Apr), was added at 1 μg/mL, and the broad spectrum MMP inhibitor, GM6001, was added at 10 μmol/L. The contraction of collagen gel was recorded and photographed.

  • 1/16

    6-Aminocaproic acid hydrochloride purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2023 Sep;193(9):1319-1334. [Abstract]

    Customer Validation
     Pharmacological blockade of plasminogen-induced endothelial cell (EC) tube regression using inhibitors targeting serine proteinases and matrix metalloproteinases. Both control (Con) ECs and ECs expressing k-RasV12 were seeded in collagen matrices for 72 hours in the presence of plasminogen (PLG) (2 μg/mL) and the indicated pharmacological agents. A competitive inhibitor of plasminogen binding to cell surfaces, 6-Aminocaproic acid (EACA), was added at 100 μg/mL, a direct inhibitor of plasmin, aprotinin (Apr), was added at 1 μg/mL, and the broad spectrum MMP inhibitor, GM6001, was added at 10 μmol/L. The conditioned medium was collected and evaluated for MMP-1 expression and activation. The conditioned media were collected at 72 hours, and Western blots were performed to assess the levels of MMP-1 zymogen and activated MMP-1.

  • 6-Aminocaproic acid hydrochloride