2732969-67-2
2732969-67-2
Chemical Structure
Pomalidomide-C5-Dovitinib
- CAS No.: 2732969-67-2
- Formula:C39H38FN9O6
- Molecular Weight:747.77
IUPAC Name: 4-((6-(4-(2-(4-amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-6-yl)piperazin-1-yl)-6-oxohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIKey: LOZMISVXTOAAHE-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(N)=C1C3=NC4=CC=C(N5CCN(CC5)C(CCCCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)C=C4N3)C(F)=CC=C2
Biological Activity: Pomalidomide-C5-Dovitinib is a heterobifunctional PROTAC that recruits KEAP1 E3 ligase to degrade BRD4 and BRD3, but not BRD2[1].
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Pomalidomide-C5-Dovitinib | Pomalidomide-C5-Dovitinib is a heterobifunctional PROTAC that recruits KEAP1 E3 ligase to degrade BRD4 and BRD3, but not BRD2. | |||||||||||||||||||||
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