SNX7886
Based on 1 Customer Validation
SNX7886 is a CDK8/CDK19 PROTAC degrader. SNX7886 promotes the ubiquitination and degradation of CDK8 and CDK19. SNX7886 also promotes the degradation of CCNC. SNX7886 can be used in cancer research.
(Pink: CDK8 and CDK19 ligand (HY-168683); Blue: Cereblon ligand (HY-131875); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.71%
- CAS 番号: 2924557-42-4
- 分子式: C52H59N9O7
- 分子量:922.08
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
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CDK8 |
CDK19 |
SNX7886 (30 nM-1 μM; 24 h) potently degrades CDK8, CDK19, and their binding partner CCNC in human embryonic kidney 293 cells, with maximal degradation observed at concentrations as low as 30 nM after 24 h of treatment[1].
SNX7886 (200 nM; 72 h) induces kinase-dependent transcriptomic changes in human embryonic kidney 293 cells, altering expression of 1435 high-confidence DEGs after 72 h of 200 nM treatment, with effects largely overlapping those of the CDK8/19 kinase inhibitor BI1347[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human embryonic kidney 293 cells
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Concentration:30 nM, 100 nM, 300 nM, 1 μM
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Incubation Time:24 h
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Result:Degraded CDK8 by up to 90% and CDK19 by up to 80%, with concurrent degradation of CCNC.
Maintained degradation of CDK8, CDK19, and CCNC at 100 nM, 300 nM, and 1 μM concentrations.
化学情報
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CAS 番号 2924557-42-4
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性状 Solid
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分子量 922.08
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分子式 C52H59N9O7
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCCCC(NCCCCCCCCCCC(N4CCN(CC4)C(CN5N=CC(C6=CC=C(C7=C8C=CC=CC8=CN=C7)C=C6)=C5)=O)=O)=O)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (108.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0845 mL | 5.4225 mL | 10.8450 mL | 27.1126 mL |
| 5 mM | 0.2169 mL | 1.0845 mL | 2.1690 mL | 5.4225 mL | |
| 10 mM | 0.1085 mL | 0.5423 mL | 1.0845 mL | 2.7113 mL | |
| 15 mM | 0.0723 mL | 0.3615 mL | 0.7230 mL | 1.8075 mL | |
| 20 mM | 0.0542 mL | 0.2711 mL | 0.5423 mL | 1.3556 mL | |
| 25 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 30 mM | 0.0362 mL | 0.1808 mL | 0.3615 mL | 0.9038 mL | |
| 40 mM | 0.0271 mL | 0.1356 mL | 0.2711 mL | 0.6778 mL | |
| 50 mM | 0.0217 mL | 0.1085 mL | 0.2169 mL | 0.5423 mL | |
| 60 mM | 0.0181 mL | 0.0904 mL | 0.1808 mL | 0.4519 mL | |
| 80 mM | 0.0136 mL | 0.0678 mL | 0.1356 mL | 0.3389 mL | |
| 100 mM | 0.0108 mL | 0.0542 mL | 0.1085 mL | 0.2711 mL |
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