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  4. SNX7886

SNX7886 is a potent protac degrader of CDK8/19. SNX7886 degrades CDK 8 and CDK 19 with 90% and 80% degradation in 293 cells, respectively.

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SNX7886 Chemical Structure

SNX7886 Chemical Structure

CAS No. : 2924557-42-4

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500 μg USD 940 In-stock
1 mg USD 1500 In-stock
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Description

SNX7886 is a potent protac degrader of CDK8/19. SNX7886 degrades CDK 8 and CDK 19 with 90% and 80% degradation in 293 cells, respectively[1].

Molecular Weight

922.08

Formula

C52H59N9O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCCCC(NCCCCCCCCCCC(N4CCN(CC4)C(CN5N=CC(C6=CC=C(C7=C8C=CC=CC8=CN=C7)C=C6)=C5)=O)=O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (108.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0845 mL 5.4225 mL 10.8450 mL
5 mM 0.2169 mL 1.0845 mL 2.1690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0845 mL 5.4225 mL 10.8450 mL 27.1126 mL
5 mM 0.2169 mL 1.0845 mL 2.1690 mL 5.4225 mL
10 mM 0.1085 mL 0.5423 mL 1.0845 mL 2.7113 mL
15 mM 0.0723 mL 0.3615 mL 0.7230 mL 1.8075 mL
20 mM 0.0542 mL 0.2711 mL 0.5423 mL 1.3556 mL
25 mM 0.0434 mL 0.2169 mL 0.4338 mL 1.0845 mL
30 mM 0.0362 mL 0.1808 mL 0.3615 mL 0.9038 mL
40 mM 0.0271 mL 0.1356 mL 0.2711 mL 0.6778 mL
50 mM 0.0217 mL 0.1085 mL 0.2169 mL 0.5423 mL
60 mM 0.0181 mL 0.0904 mL 0.1808 mL 0.4519 mL
80 mM 0.0136 mL 0.0678 mL 0.1356 mL 0.3389 mL
100 mM 0.0108 mL 0.0542 mL 0.1085 mL 0.2711 mL
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SNX7886 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNX78862924557-42-4SNX 7886SNX-7886PROTACsPROTAC DegraderCDK8/19293 cellInhibitorinhibitorinhibit

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