ZS3-046
ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model.
(Pink: TAF1 ligand (HY-176467); Blue: Cereblon ligand (HY-41547); Black: linker (HY-176469)).
For research use only. We do not sell to patients.
- CAS No.: 3087879-97-5
- Formula: C49H57N9O7
- Molecular Weight:884.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 3087879-97-5
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Molecular Weight 884.03
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Formula C49H57N9O7
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SMILES
O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCN5C6=C(C(C(C7=C8NC=C7)=CN(CCC=C)C8=O)=CC(C(N9CCOCC9)=O)=C6)N=C5)CC4)C=CC=C3C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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